GEGL (the upcoming GIMP backend) uses linear-light floating point as the main pixel format. Krita allows several colorspaces and color management through LittleCMS. What about MyPaint? Version 0.5.x uses 8bit sRGB without any alpha channel. Time for a change.
I have settled now with a 16bit integer for each channel, permultiplied alpha, no linear light (gamma as in sRGB). The extra precision helps against the noise when blitting many faint dabs on top of each other. Here you can see the difference (click to enlarge):
A more subtle point is that white (or opaque alpha) is not stored as 2^16-1 but as 2^15. So, after multiplying a component with the alpha channel, the neccessary division by 2^15 can be done with a simple bit shift (fixed-point arithmetic). So effectively only 15 bits are used. Nobody will miss that final bit of precision.
I also have read quite a bit about linear light and even did a test implementation. But after a short painting session I came to the conclusion that, while the effect for painting is subtle, it is mostly counter-intuitive. Especially the fact that white is “stronger” than black. I’m sure there are some special situations where it works better (eg zooming, and maybe layer compositing in some special cases), but right now, linear light is no longer a topic for me.
The advantages of premultiplied alpha have been discussed more than enough elsewhere. I just want to share one little pleasant surprise: my almost unoptimized C implementation blitting 16bit premultiplied RGBA onto 8bit RGB is three times faster than gdk-pixbuf blitting 8bit RGBA onto 8bit RGB.